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Effects of Dendroaspis natriuretic peptide on cardiovascular and renal functions in acute hypertensive rabbits
Author(s) -
Kim Sun Young,
Kim So Young,
Park Sung Hun,
Kim Suhn Hee,
Cho Kyung Woo,
Kim Sung Zoo
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a824-c
Subject(s) - natriuresis , diuresis , medicine , endocrinology , urinary system , urine , excretion , norepinephrine , renal function , natriuretic peptide , chemistry , heart failure , dopamine
The purpose of this study was to define the effects of Dendroaspis natriuretic peptdie (DNP) on cardiovascular and renal functions in rabbits in acute hypertensive states induced by a infusion of norepinephrine(NE). Urine volume, urinary Na + , K + and Cl − excretions measured during six 20 min collection periods, three prior to and three following DNP treatment. BP increased ~30 mmHg within 5 min of initiation of continuous NE infusion, and then gradually dropped to ~20 mmHg over baseline after 80 min. Within 15 min of treatment with 30 μ/kg DNP, BP was significantly decreased as compared with controls. Intravenous administration of DNP (1, 10, and 30 μ/kg) to rabbits resulted to increase of diuresis and natriuresis, and a decrease in systolic BP. Urine flow, urinary Na + , K + and Cl − excretion, and GFR were increased at different rate. By DNP treatment, plasma and urinary cAMP levels were increased over 2 folds compare with the vehicle. Plasma and urinary cGMP levels were increased over 3 folds in the administration of DNP (10, 30μ/kg). BP, electrolytes, urinary cAMP, and cGMP levels in the administration of DNP (10μ/kg) were greatly higher than that in the administration of DNP (30μ/kg). These results indicate that DNP markedly reduced BP, and increased diuresis and natriuresis in acute hypertensive states, and suggest that DNP has a possibility of its potential use in the treatment of cardiovascular disease states related to catecholamine activation. (supported by a grant of Center for Healthcare Technology Development, Ministry of Education & Human Resources Development)