Premium
No effect of menstrual cycle phase on VLDL‐triglyceride and apoB‐100 kinetics
Author(s) -
Magkos Faidon,
Patterson Bruce W.,
Mittendorfer Bettina
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1467-b
Subject(s) - medicine , endocrinology , apolipoprotein b , very low density lipoprotein , luteal phase , chemistry , triglyceride , menstrual cycle , lipoprotein , menopause , hormone , cholesterol , follicular phase
Premenopausal women have a lower risk of cardiovascular disease (CVD) than postmenopausal women and age‐matched men, partly due to lower plasma triglyceride (TG) and higher HDL‐cholesterol concentrations. This suggests that ovarian hormones have a beneficial effect on lipoprotein metabolism, although hormone replacement therapy does not always reverse the effects of menopause on CVD risk factors. The impact of variations in the availability of ovarian hormones during a normal menstrual cycle on plasma TG concentration is uncertain and its effect on lipoprotein metabolism has never been studied. We measured VLDL‐TG and apoB‐100 kinetics by using stable isotope labeled tracers in 6 healthy women (age: 27±3 y, BMI: 26±2 kg/m 2 ; means±SEM) during the mid‐follicular (FP) and mid‐luteal (LP) menstrual cycle phases (plasma progesterone: 0.4±0.1 and 8±2 ng/mL, p<0.05; estradiol: 70±20 and 91±24 pg/mL; FP and LP, respectively). There were no differences between FP and LP in the plasma concentrations of free fatty acids (330±32 and 340±35 μM), VLDL‐TG (0.28±0.04 and 0.29±0.05 mM) and VLDL‐apoB‐100 (1.8±0.3 and 1.9±0.3 mg/dL). Also, no differences existed between FP and LP in the hepatic secretion rates of VLDL‐TG (8.3±0.6 and 8.1±1.2 μmol·min −1 ) and VLDL‐apoB‐100 (19±3 and 20±2 mg·h −1 ). Consequently, plasma clearance rates of VLDL‐TG and VLDL‐apoB‐100 were not different during FP and LP. We conclude that menstrual cycle phase does not affect VLDL‐TG and apoB‐100 kinetics. Hence, it is not important to control for menstrual cycle phase in studies evaluating VLDL‐TG and apoB‐100 kinetics. Supported by grants from the NIH and the AHA.