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Changes in limb, skin, and viscera vascular resistance evoked by fear‐induced stress
Author(s) -
Hayashi Naoyuki,
Someya Nami,
Maruyama Toru,
Hirooka Yoshitaka,
Fukuba Yoshiyuki
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1429-c
The changes in vascular resistance (VR) during fear‐induced stress were characterized by recording the mean arterial pressure (MAP), heart rate (HR), skin blood flow in the index finger and forehead (laser‐Doppler flowmetry), limb blood flow in the calf and forearm (plethysmography), and blood flow in the renal and superior mesenteric arteries (simultaneous pulsed and echo Doppler ultrasound). Eight subjects watched a 3‐minute video with fearful content (i.e., part of a horror movie) after resting baseline data were acquired for 2 minutes. Minute‐by‐minute data were calculated. The blood flow was divided by the MAP to assess the VR. While a clear steady state was not evident in the stress‐induced vascular response, the stress significantly increased the MAP and HR (e.g., by 10±3 mmHg and 7±3 bpm at the 2nd minute, respectively; mean±SEM), and the VR of the forearm and finger skin (e.g., by 80±26% and 79±28% at the 2nd minute, respectively). The VR increased slightly in the calf and visceral arteries but not in the forehead throughout the stimulation. None of the variables differed significantly from baseline at the 1st minute after the cessation of the stimulation. These results suggest that fear‐induced stress induces vasoconstriction mainly in the forearm and finger. (supported by Uehara Memorial Foundation, and JSPS)