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Formation of a Bioactive Layer on a Conductive Polymer
Author(s) -
Osterloh Jeannette Michelle,
Karplus Christina,
Immoos Chad
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1351-b
Phage display panning techniques were used to isolate peptides that bind specifically to the polymer Poly [2‐methoxy‐5‐(2‐ethylhexyloxy)‐1,4‐phenylenevinylene] (PPV). This polymer is a light‐emitting conductor that is currently used in solar cells and nanotube OLEDS. These peptides will be used to form a bioactive layer that allows for the use of this polymer in biological systems without the chemical modification of the polymer surface. The phage display peptide libraries utilized in this study were a NNK 12mer and a constrained 10mer containing a fixed disulfide bond. The results of panning, including the structure of the selected peptides, initial binding studies, and characterization of phage‐polymer interactions, will be presented. This work was supported by the Department of Chemistry College Based Fee Program, California Polytechnic State University, San Luis Obispo.