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Study of protective effect of ginseng panaxadiol on assay the index of biochemistry of myocardial ischaemia
Author(s) -
Zeng Qing hua,
Liu Jun
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1288-a
Background Previopus studies have demonstrated that ginseng panaxadiol saponin monomer RB1 have protective effect of endothlin‐1 induced myocardial ischaemia. Oblective This study is to examine protective effects of myocardial ischaemia by (IH) induced with ginseng panaxadiol (PDS) comepared with nitroglycerin and issosorbide dinitrate in assay the index of biochemistry. Method These experiments used Wistar adult rat of health. To make animal model by IH, isosorbide dinitrate as positive control, examine the effect of PDS, these durg were injected into a vine after 30min, take out hearts and to determine SOD (active unite/ml) by the method of he huang su‐NBT, to determine CAT (10‐4kg/Hb) by the method of H2O2, to determine LPO (by this method of TBA. Results These result indicate that effect of PDS. Normal of SOD, CAT, LPO were separately 19.77+/−5.85, 3.754+/−2.74, 0.314+/1.236, after used (IH), the SOD, CAT, LPO were separately 21.678+/6.18, 2.936+/−1.96, 0.346+/0.28, after used isosorbide dinitrate, SOD, CAT, LPO were separately 21.15+/−0.65, 1.394+/−0.92*, 0.4825+/−0.08, however, after used PDS, the SOD, CAT, LPO were separately 23.61+/−1.95, 1.410+/−0.06*, 0.346+/−0.33. Conclusion These result show to increase these concentration of enmyzy by PDS and enhand the effect of resisting free base of oxygen, so PDS have protective effect on myocardial ischaemia.