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WISE‐2005: 60 days head‐down bed rest causes a shift towards a pro‐atherosclerotic environment
Author(s) -
Mattar Louis,
Rush James W.E.,
Shoemaker J. Kevin,
Arbeille Philippe,
Hughson Richard L
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1254-b
Subject(s) - bed rest , rest (music) , medicine , chemistry , nitric oxide , endocrinology
This study reports on the first 12 subjects of the Women International Space Simulation for Exploration (WISE) who completed 60 days of head‐down tilt (HDT) bed rest to test exercise and nutrition countermeasures compared to controls. We hypothesized that exercise would prevent an increase in pro‐atherosclerotic factors associated with the inactivity of bed rest. Blood samples were collected before and at the end of bed rest to examine the difference in angiotensin II (ANG II), adhesion molecules (ICAM, VCAM, and e‐SEL), and nitric oxide metabolites (NO met ), among others. ANG II was increased in both of the non‐exercising groups (nutrition and control combined increased from 11.34±2.2pg/ml to 25.5±5.5pg/ml) but not in the exercise group (16.1±3.9pg/ml and 14.1±3.6pg/ml). ICAM and e‐SEL showed no change; however VCAM increased in the non‐exercising groups after the bed rest (584.8±23.8ng/ml and 630.2±17.0ng/ml). ANG II is known to increase the formation of reactive oxygen species (ROS), and may be a reason for the decrease seen in the levels of NO met in the non‐exercising groups (40.1±3.4μM and 26.5±3.8μM) but not in the exercising group (50.98±9.73μM to 47.88±5.21μM). 60 days of bed rest in HDT causes a shift in some factors towards a pro‐atherosclerotic state while regular exercise during the bed rest prevented these changes. Supported by Canadian Space Agency, NASA, ESA, CNES