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COMPARISON OF NATRIURETIC PEPTIDES A AND B IN CARDIAC PATIENTS WITH DIFFERENT DEGREE OF LEFT VENTRICULAR SYSTOLIC DYSFUNCTION
Author(s) -
Kukacka Jiri,
Kotaska Karel,
Popelova Jana,
Vrzanova Marie,
Prusa Richard
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1196-b
Subject(s) - ejection fraction , medicine , cardiology , natriuretic peptide , brain natriuretic peptide , heart failure
Aim of the study was to compare the sensitivity of atrial and brain natriuretic peptides (proANP, BNP, NT‐proBNP) for the detection of cardiac involvement with different degree of left ventricular systolic dysfunction. Roche NT‐proBNP, Bayer Shionoria BNP and BRAHMS LIA proANP assays were performed in 44 patients (mean age 50 years; range 20–79 years) with various types of heart disease (coronary, valvular and congenital) and different impairment of left ventricular systolic function assessed by echocardiography. Patients were divided into four groups according to the left vetricular ejection fraction (LVEF): group I: LVEF<25%, group II: LVEF 26–40%, group III: LVEF 41–59%, group IV: LVEF>60%). Serum NT‐proBNP levels and plasma BNP and proANP levels expressed as median+SEM in four groups were as follows: Group I–NT‐proBNP=2082+1018 pg/ml, BNP=548+210 pg/ml, proANP=3080+628 pg/ml;group II–NT‐proBNP=394+281 pg/ml, BNP=115+43 pg/ml, proANP=1196+159 pg/ml; group III–NT‐proBNP=354+132 pg/ml, BNP=68+27 pg/ml, proANP=1547+409 pg/ml; group IV‐NT‐proBNP=168+51 pg/ml, BNP=146+39 pg/ml, proANP=1236+213 pg/ml. Statistical analysis at a value of P<0.05 was used to distinguish severity of the left ventricular impairment. The medians of NT‐proBNP, BNP and proANP between the groups were significantly different (P=0.0064, P=0.0099, P=0.0029). Natriuretic peptides are sensitive markers for the distinguishing severe left ventricular impairment (LVEF<25%) from the less severe impairments. This work was supported by grant MZO 00064203‐6306.