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Vitamin E reduces myocardial infarct size in type 2 diabetes
Author(s) -
DavisGorman Grace Frances,
Gonzales Raoul,
Cohen Zoe,
McDonagh Paul F.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1153-c
Subject(s) - medicine , type 2 diabetes , myocardial infarction , diabetes mellitus , vitamin , cardiology , endocrinology
The interrelationship of type 2 diabetes (T2D), inflammation and ischemic heart disease (IHD) is not clear. We suspect that a low‐level, chronic inflammatory response aggravates leukocyte‐mediated ischemia‐reperfusion (I/R) injury in the T2D heart. The purposes of this study were to: 1.) determine if myocardial injury due to I/R was increased in the Zucker Diabetic Fatty (ZDF) model of T2D, 2.) determine if treatment with vitamin E would attenuate ischemic injury. Zucker Lean Controls (ZLC) and ZDF rats were subjected to a left anterior descending coronary artery occlusion‐reperfusion protocol. The recovery of left ventricular function and myocardial infarct size were determined. Neutrophil reactive oxygen species (PMN ROS) was measured in whole blood prior to ischemia. Four groups were studied. Group 1: ZLC‐Placebo, Group 2: ZLC‐Vit E, Group 3: ZDF‐P and Group 4: ZDF‐E. We found that the recovery of ventricular function (+dP/dt) was somewhat depressed in the diabetic group (ZLC‐P = 87.4% ± 11.7 SEM, ZDF‐P = 68.1% ± 5.5, P=NS), however, the recovery of the ZDF‐E group was improved significantly (ZDF‐E = 97.4% ± 10.3). The myocardial infarct size was significantly increased in the ZDF‐P group but was reduced with vitamin E treatment (ZLC‐P = 43.0% ± 1.9, ZDF‐P = 57.0% ± 3.9, ZDF‐E = 33.9% ± 5.1, P≤0.05). In addition, vitamin E treatment significantly reduced the chronic increase in PMN ROS observed in the ZDF‐P group (P≤0.05). These findings indicate that ischemic injury is significantly increased in the ZDF heart and is associated with increased PMN ROS. Treatment with vitamin E reduced both PMN ROS and the severity of IHD in T2D. Supported by NIH HLB 58859.