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Hepatoprotective and Antifatigue effects of Lactic acid bacteria (Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus) in SD rats and ICR mice
Author(s) -
Ha Nam Joo,
Kim Yun A,
Kang Byung Yong,
Chung Myung Jun
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1147-b
Subject(s) - bifidobacterium bifidum , lactobacillus acidophilus , streptococcus thermophilus , lactic acid , chemistry , bifidobacterium , probiotic , aspartate transaminase , food science , lactobacillus , pharmacology , microbiology and biotechnology , alkaline phosphatase , bacteria , medicine , fermentation , biochemistry , biology , genetics , enzyme
Lactobacillus acidophilus, Bifidobacterium bifidum and Streptococcus thermophilus are potent probiotic lactic acid bacteria (LAB) that used in commercial fermented dairy products. These strain are play a important roles in human health include a lowering the levels of serum cholesterol, vitamin synthesis, improving lactose intolerance, maintaining the balance of intestinal microflora and anti‐cancer activity. The main aim of this study was investigate that hepatoprotective activity‐carbon tetra chloride and ethanol (25%) induced liver injury in SD rats‐and antifatigue effects were evaluated. To investigate the hepatoprotective effect, rats treated with CCl4 and ethanols were analyzed with serum glutamic pyruvic transaminase (s‐GPT) and serum glutamic oxaloacetic transaminase (s‐GOT) level. These lactic acid bacteria (LAB) could afford a significant protection in the alleviation of CCl4 and ethanol‐induced hepatocellular injury. The antifatigue activity of LAB was studied in ICR mice, using forced swimming test, horizontal wire test and rotarod test. The LAB (orally inoculated mixture of LAB for 3weeks) showed a significant antifatigue effect in test group. These results suggested that LAB have hepatoprotective activity and antifatigue effect.