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Method to evaluate the pharmacological activity of herbal medicine upon the heart (Bufo spinulosus)
Author(s) -
Gutierrez Alfonso J.,
Villavicencio Victor R.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1146
Subject(s) - epinephrine , rosmarinus , officinalis , medicine , traditional medicine , tachycardia , anesthesia , bradycardia , qt interval , pharmacology , heart rate , blood pressure
The open heart preparation of Bufo spinulosus (n=24) was used to study the effect of extracts from herbal medicine ( Rosmarinus officinalis , Melissa officinalis , Sanguisorba officinalis and Trichocereus pachanoii ) and compare them to standard pharmacological products (epinephrine, pilocarpine and epinephrine+pilocarpine) and electrolites (KCl and CaCl 2 ). Electrodes are placed on the skin surface and ECG recorded before and after instillation directly on the heart. The extracts were prepared following the method of ethanol extracts. Results were the effects of bradycardia and tachycardia of CaCl 2 and epinephrine, respectively. Similar behavior is also shown by Sanguisorba officinalis and Trichocereus pachanoii . P wave was prolonged by herbal medicine, R wave was prolonged by Rosmarinus officinalis (0.61Vs, 17%), T wave was prolonged by epinephrine (1.94 Vs, 185%) and Trichocereus pachanoii (1.65 Vs, 157%), PR interval was prolonged by epinephrine (62ms, 18%) and medicinal herbal, QT interval was decreased by herbal medicine, and ST segment was prolonged by epinephrine (73ms, 31%) and Trichocereus pachanoii (78ms, 34%). Finally, further research will be conducted on those compounds that showed biological effects upon the heart. Supported in part by ONG Centro de Enseñanza, Investigación y Servicios.