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AN INVITRO STUDY OF THE PHARMACOLOGICAL EFFECTS OF EXTRACTS FROM THE LEAVES OF ALSEODAPHNE PERAKENSIS
Author(s) -
Okechukwu Nwabueze Patrick,
Rosli Rozita,
Lajis Nordin,
Pook Peter,
Sam Soh Kai,
Raj Vijayah Lechimi
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1145-d
Subject(s) - alkaloid , histamine , chemistry , traditional medicine , anticholinergic , pharmacology , arbutin , botany , medicine , biology , chromatography , stereochemistry
The alkaloid extract from methylene chloride of Alseodaphne perakensis(AP) was evaluated quantitatively on guinea pig ileum(GPI). AP belongs to the family of lauraceae. It is a tree of moderate size that is widely distributed throughout Peninsular Malaysia. There has been lack of reported use of this plant n traditiona folk medicine. Although tests has shown its leaves are rich in alkaloids. Similar alkaloids extracted from other plants has been reported to act as remedy for gastric pains, rheumatism, and muscle relaxant, also as antiemetic agent. The crude extract from AP was extracted using methanol followed by fractionaton with methylene chloride to extract the alkaloid. The effects of alkaloid extract on GPI were evaluated in an organ bath using Krebs solution as the tissue medium. The alkaloid extract from AP antagonized in a non‐competitive and concentraction‐dependant manner, the contractions induced by histamine and acetylcholne on the unstimulated GPI. From this study it may be concluded that the alkaloid extract from the leaves of AP appear to posses antihistaminergic and anticholinergic properties.