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The effect of citrate, maltolate and fluoride on oral 26 Al absorption
Author(s) -
Zhou Yuzhao,
Yokel Robert A.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1141
Subject(s) - bioavailability , chemistry , fluoride , antacid , absorption (acoustics) , nuclear chemistry , cmax , medicine , inorganic chemistry , pharmacology , biochemistry , materials science , composite material
Aluminum (Al) has been suggested to contribute to dialysis encephalopathy, an osteomalacia, an anemia and Alzheimer's disease. The objectives were to investigate 1) the absolute oral bioavailability of 4 representative chemical species of Al, at an Al concentration between that produced by drinking water and antacid/phosphate binder use, and comparable ligand concentration, 2) whether the ligand has an influence on Al bioavailability, T max , and C max , and 3) whether the Al was absorbed as the Al complex. Male Fisher rats were orally administrated ~ 1 nCi 26 Al (65 μM; 1750 μg/l) as the ion, or as a 1:1, 1:3 or 1:4 complex with 14 C‐citrate (Cit), 14 C–maltolate (Malt), or fluoride (F), respectively, during concurrent 27 Al i.v. infusion. Blood samples were collected up to 24 h. Serum 26 Al and 14 C were quantified by accelerator mass spectrometry; 27 Al by atomic absorption spectroscopy. Results were analyzed using WinNonlin and expressed as mean ± SD.None of the differences in the 3 endpoints was statistically significant among the Al species. The 14 C concentration was ~100 times higher than expected if the 14 C was absorbed as the Al complex, suggesting considerable dissociation of Al Cit and Al Malt in the GI tract. The within subject‐time course of serum 26 Al and 14 C overlapped, suggesting that the Al might be absorbed as the Cit and Malt. The presence of Cit, Malt and F at the Al concentration and Al:ligand ratios studied had only a small effect on Al absorption. Funded by EPA STAR Grant 829783