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Sophorae Radix reduces autoimmune response in NZB/w F1 lupus mice model
Author(s) -
Ko Eunjung,
Lee Youngseop,
Park Namhee,
Kim Dongwoo,
Shin MinKyu,
Hong MooChang,
Bae Hyunsu
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1128-d
Subject(s) - systemic lupus erythematosus , proteinuria , medicine , titer , splenocyte , antibody , immunology , antibody titer , autoimmune disease , population , endocrinology , lupus nephritis , disease , kidney , environmental health
Sophorae Radix (SR) is commonly used as febrifugal medicine in Asian countries such as Koera, China and Japan, The immunosuppressive effect of SR have been suggested to be applicable for the treatment of autoimmune disease. We investigated the effect of SR on lupus nerphritis as a model of NZB/w F 1 mice. Three‐month‐old NZB/w F 1 mice were separated into two group : one treated with SR (1% SR solution by oral, daily for 15weeks) and one with water as a control. Experimental parameters include proteinuria, anti‐dsDNA antibody titers, T cell response and renal histopathology. SR treated mice resultes in significant reduction of proteinuria, reduced anti‐dsDNA antibody titer. Population of lymphocytes in blood was significantly increased in the treated mice than in control. Cytokine production IFN‐γ in splenocytes were significantly reduced in treated mice compared with control, while increasing IL‐4 in splneocytes. Our data demonstrated that SR therapy attenuated severity in NZB/w F 1 mice. SR treatment may be of use in the clinical treatment of lupus patients and it would be benefit for futher studies. This work was supported by a grant of Oriental Medicine R&D Project, Ministry of Health & Welfare, Republic of Korea (HMP‐00‐CO‐02‐0002)