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Gene Expression Patterns: Human Blood Cells Exposed to Common Flu‐like Viruses
Author(s) -
Mayda Maria Esther,
Zapata Juan Carlos,
Hammamieh Rasha,
Das Rina,
Djavani Mahmoud,
Lukashevich Igor,
Moshkoff Dmitry,
Salvato Maria,
Jett Marti
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1103-c
Subject(s) - rhinovirus , biology , virology , respiratory tract infections , immunology , virus , peripheral blood mononuclear cell , respiratory tract , immune system , gene , common cold , reassortment , pneumonia , respiratory system , medicine , covid-19 , disease , in vitro , genetics , pathology , infectious disease (medical specialty) , anatomy
The common, community‐acquired viral infections, though often self‐limiting, can develop into debilitating or deadly respiratory illnesses. Historically, rhinoviruses, human coronaviruses, and adenoviruses cause upper respiratory tract infections, whereas influenza, respiratory syncytial virus (RSV), and parainfluenza viruses are commonly found in cases of lower respiratory tract infection (acute bronchitis, pneumonia). We have studied the effect of 4 virus infections (Flu A, Parainfluenza, rhinovirus and RSV), in comparison with several emerging viral infections at multiple time periods on gene expression in Peripheral Blood Mononuclear Cells (PBMC) using spotted cDNA microarrays for analysis of 9,000 human genes. Common sets of genes were induced by these viruses as were sets specific for each of the 4 viruses. Gene responses that were altered included the immune, cell adhesion, inflammatory, and antiviral pathways. Early changes in gene expression were seen two hours post‐infection of PBMCs. Correlation of these genes with in vivo exposure provides the opportunity to identify diagnostic and therapeutic markers that may provide early indicators of impending severe illness.