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Long term dietary supplementation of organic selenium enhances expression of immune related genes in adult pigs
Author(s) -
Kim Sung Woo,
Dowd Scot E,
Mateo Ronaldo D,
Yoon Ilkyu
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1069-c
Subject(s) - selenium , immune system , gene , biology , term (time) , physiology , zoology , immunology , chemistry , genetics , organic chemistry , physics , quantum mechanics
Ninety six pigs at 34.4 kg weight were allotted to two dietary treatments with 6 replicates per treatment and 8 pigs per pen: the control (no added Se) and the OS (0.36 mg/kg added Se from Se enriched yeast). Pigs were fed for 110 days until 130.0 kg body weight based on 3 phase feeding programs with nutrient levels recommended by National Research Council only except for Se. The control diet contained 0.18 mg/kg indigenous Se whereas the OS diet contained 0.54 mg/kg Se. Blood samples were collected at 1000 h and further processed for the microarray analysis. Microarray chips were prepared with 800 genes related to immune function of pigs. Among those, 27 genes related to improved immune status and innate immunity were up‐regulated (P < 0.05) and those include growth arrest homeobox transcription factor (43.9%), toll‐like receptor 2 precursor (12.2%), vanin‐1 (65.5%), lysozyme C‐3 precursor (10.8%), amyloid beta A4 protein precursor (91.1%), integrin beta‐1 subunit (20.0%), myelin and lymphocyte protein (51.2%), etc. This study indicates that long term dietary supplementation (0.3%) of Se as an organic form improves the expression of genes that are related to enhanced immunity of pigs.