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MODULATING EFFECTS OF IGF I AND LEPTIN LEVELS ON BONE MINERAL CONTENT
Author(s) -
Suarez Cristina Graciela,
Ferreira Andrea,
Rodriguez Patricia,
Zeni Susana,
Friedman Silvia
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1065
Subject(s) - leptin , medicine , endocrinology , weanling , bone mineral content , chemistry , calorie , calcium , appetite , bone mineral , obesity , osteoporosis , biology
Knowledge the strong relationship between body lipid size and serum leptin levels due to its appetite regulation and the insulin like growth factor (IGF) I involved as a signal of calories, body lipid composition and proteins viability, it is important to begin to answer questions concerning bone formation throughout leptin and IGF I receptors. The aim of this study was to evaluate the strong association among leptin and IGF I levels during active growth. Forty two weanling Wistar rats were randomly assigned one of three diets providing a carbohydrate to lipid calorie ratio of 1:1 (reference group) (a) or 3:1, with either 0.6% or 0.3% of calcium content (b and c, respectively). At age= 35 d, animals were sacrificed. Body weights (BW=g) and lengths (BL=cm) were measured and body composition (% body fat by chemical method AOAC) and bone mineral content (BMC) (DEXA Lunar DPX) were determined. In five of them serum IGF I and leptin levels were measured (ELISA ng/ml). Results as mean ± SD.Diets in which lipids were restricted (b and c), affected the % of body fat and bone mineral content. Body length remained unchanged in adequate calcium diets while there was a tendency towards serum IGF I and leptin levels more diminished in b and c, than a. Serum IGF I and leptin appear to account for an accurate bone tissue development. Awarded by UBACyT O 004.