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The immuno‐modulatory effects of ornitine α‐ketoglutarate, arginine, and glutamine in postoperative rats with parenteral nutrition
Author(s) -
Lo HuiChen,
Tsai FuAnn
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1056-d
Subject(s) - glutamine , arginine , parenteral nutrition , splenocyte , medicine , endocrinology , spleen , immune system , tumor necrosis factor alpha , chemistry , biochemistry , immunology , amino acid
Our previous study demonstrated that intravenous supplementations of arginine, glutamine, and ornitine α‐ketoglutarate (OKG), a precursor of arginine and glutamine, significantly attenuate surgical stress‐induced alterations in serum tumor‐necrosis factor (TNF)‐α and interleukin‐4 in rats. The aim of this study was to further compare their effects on immune response. Male Wistar rats (~250 g) performed with jugular vein cannulation and midline abdominal incision were provided with conventional or OKG, arginine, or glutamine supplemented total parenteral nutrition solution for 7 days. Our results showed that supplementations of OKG, arginine, and glutamine significantly decreased T‐helper and T‐suppressor cells and increased NK cells in the peripheral blood and significantly decreased the ability of T cell proliferation in the thymus. OKG significantly increased T‐helper and T‐suppresser cells and decreased B cells in the spleen. Glutamine significantly increased the abilities of TNF‐α production in the T‐ and B‐cells of the peripheral blood and in the B‐splenocytes. Our results suggested that parenteral supplementations of OKG, arginine, and glutamine may have immuno‐modulatory effects in rats with surgical stress. (NSC‐92‐2320‐B‐371‐001)