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Pre‐ and Postprandial Appetite Hormone Levels in Normal Weight and Obese Women
Author(s) -
Turpin Amy Allen,
Carlson Joseph,
Bucci Luke,
Adams Ted,
Hunt Steven
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1036
Subject(s) - postprandial , ghrelin , medicine , leptin , endocrinology , appetite , adiponectin , hormone , obesity , meal , insulin , insulin resistance
We compared pre‐and post‐prandial appetite hormone (ghrelin, leptin, adiponectin, insulin) responses in obese (OB) and normal weight (NW) women at a University Clinical Research Center. Twenty‐three (13 OB; BMI = 44.5 ± 7.1 kg/m2) and 10 NW; BMI = 23.1 ± 1.3 kg/m2) women completed the study. Baseline and 5 postprandial blood samples were measured over a 2 h period following a high CHO meal. There were significant differences between groups for all hormones at baseline. Post prandial leptin responses were significantly different between groups (p < 0.001). Averaged over time, the OB group had a significantly higher leptin response than the NW group (p < 0.001). Postprandial ghrelin responses showed a trend for a difference between groups (p = 0.06). Averaged over time, the NW group had a significantly higher ghrelin response than the OB group (p = 0.004). For adiponectin, the postprandial response was significantly different between groups (p = 0.04). Averaged over time, the adiponectin response was significantly higher in the NW than in the OB women (p = 0.015). For insulin, the postprandial response was not significantly different between groups (p = 0.260), but averaged over time, it showed a trend to be higher in the OB group than in the NW group (p = 0.06). These results indicate there are significant differences pre‐ and post‐prandially in ghrelin, leptin, and adioponectin between OB and NW women. Understanding how these differences in appetite hormones influence eating and body composition has potential for treating obesity and maintaining a desirable body weight.