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Influence of BMI and gender on time course of post‐prandial hormone responses
Author(s) -
Carroll Joan F,
Franks Susan,
Kaiser Kathryn,
Deere Curtistine,
Caffrey James L
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1035-a
Subject(s) - medicine , ghrelin , endocrinology , insulin , glucagon , meal , leptin , body mass index , hormone , insulin resistance , radioimmunoassay , obesity
The purposes of this study were a) to identify the time of peak post‐prandial hormone response, and b) to determine whether body mass index (BMI) grouping or gender altered the time course of post‐prandial hormone responses. Normal weight (NW, BMI < 25)(n=9) men, NW women (n=11) obese men (BMI > 30) (n=9) and obese women (n=10) were recruited. Fasting blood samples were taken to measure glucose, insulin, leptin, ghrelin, GLP‐1, and glucagon. After consuming a liquid Slim·Fast meal, blood samples were taken every 10 min over the next hour. Plasma samples were analyzed by radioimmunoassay. Data were analyzed using a repeated measure ANOVA with BMI group and gender as main effects. Peak responses for glucose, insulin, ghrelin, and glucagon occurred after 20‐40 min, while GLP‐1 and leptin demonstrated no post‐prandial response. There were time X BMI group effects on both plasma glucose (p=0.015) and insulin (p=0.001). Plasma glucose and insulin both increased after the liquid meal in NW and obese, but obese subjects had greater post‐prandial increases and significantly greater values at 60 min post‐meal. Obese males in particular had greater fasting and 60‐min post‐prandial HOMA scores (insulinXglucose/22.5), suggesting greater insulin resistance compared with the other groups. Glucagon exhibited a time X gender effect (p=0.02), with males having a greater glucagon at rest and at all time points. Ghrelin decreased after the meal, but there were no BMI group or gender differences in the response. Thus, while an optimum time for post‐prandial blood sampling was identified, body composition and gender both significantly affected selected post‐prandial hormone responses. Support by H75/CCH224064, HL04297, HL64913.