Premium
Single Dose Pharmacokinetics of Highly Unsaturated Fatty Acids (HUFA) in Children and Adults
Author(s) -
Surette Marc E,
Koumenis Iphigenia
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1029-b
Subject(s) - eicosapentaenoic acid , pharmacokinetics , triglyceride , medicine , fatty acid , chemistry , pharmacology , polyunsaturated fatty acid , biochemistry , cholesterol
There are little or no data on the pharmacokinetics (PK) of HUFA in children although fatty acid supplements are accessible to this group. The objective of this study was to compare the 24‐hour PK of a single dose of dietary gammalinolenic acid (GLA) and eicosapentaenoic acid (EPA) as triglyceride oils in adults and children. Subjects aged 6–11, 12–17 and 18–45 years received a 4g, 10g and 10g dose of emulsion, respectively, containing 165 μmoles EPA and 270 μmoles GLA per gram. Plasma GLA and EPA were determined by GC with FID detection from blood samples collected at predose and at 0.5, 1, 1.5, 2, 2.5, 3, 4, 6, 8, 12 and 24 hrs after administration. PK parameters were estimated by non‐compartmental techniques. The Table below summarizes the main PK results obtained:The provided doses produce comparable AUCs and C max s in children and adults. EPA showed different PK characteristics than GLA and younger children absorbed EPA faster than the other groups. There were no trends that would raise any safety concerns (e.g. liver and renal function tests). This study was carried out with standards that reflect the U.S. Code of Federal Regulations for the conduct of clinical studies. Supported by Pilot Therapeutics, Inc.