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Hypolipidemic effect of a sorghum fraction in combination with other natural nutraceutical ingredients in the hyperlipidemic Syrian hamster
Author(s) -
Burdette Amy Lee,
Greenspan Phillip,
Hargrove James L.,
Hartle Diane K.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1027-d
Subject(s) - nutraceutical , cholesterol , sorghum , triglyceride , chemistry , very low density lipoprotein , food science , biology , lipoprotein , biochemistry , agronomy
These experiments tested the hypocholesterolemic actions of a sorghum fraction in combination with four other natural ingredients to produce an effective cholesterol lowering formulation for nutraceutical supplement products. Male golden Syrian hamsters were fed a hypercholesterolemic diet containing 5% coconut oil and 0.12% cholesterol. The test sorghum fraction was 5% of the diet with the four other substances constituting only 1.2% of the diet. A cellulose group was included to control for diet displacement by the sorghum fraction. After three weeks, plasma total cholesterol, HDL cholesterol and triglycerides were determined. Food intake, body weights, liver weights and epididymal fat pad weights were also measured. The hypercholesterolemic diet increased plasma cholesterol concentrations from 134 mg/dl to 254 mg/dl, while animals that were fed the nutraceutical formulation increased to only 145 mg/dl. Plasma triglyceride concentration and the ratio of LDL + VLDL cholesterol to HDL cholesterol were also significantly decreased. There were no significant differences between groups in consumption of food, weight gain, liver weight, epididymal fat pad weight or plasma HDL cholesterol. In conclusion, this experiment demonstrates the beneficial preventative effect of the sorghum formulation on plasma lipids in the hyperlipidemic Syrian hamster model. (Supported by: USDA Grant # 5854304363, UGARF IP #1048, Patent Pending)