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The nutritional regulation on the expression of adiponectin receptor genes in pigs
Author(s) -
Ding ShihTorng,
Liu B. H.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1023-b
Subject(s) - adiponectin , adipose tissue , adiponectin receptor 1 , medicine , endocrinology , biology , receptor , adipocyte , gene expression , gene , insulin , insulin resistance , biochemistry
Adiponectin is an adipocyte‐derived hormone, which appears to be both insulin‐sensitive and anti‐inflammatory. There are two subtypes of adiponectin receptors (AdipoR1 and AdipoR2) and they mediate the effect of adiponectin in tissues to regulate glucose and fatty acid metabolism. Using the cloned porcine AdipoR cDNA as probes, we found that the AdipoR2 was highly expressed in porcine adipose tissue whereas the AdipoR1 was highly expressed in the liver and muscle. The expression of both AdipoR mRNAs in muscle was not different between the pre‐prandial and post‐prandial condition. The expression of both AdipoR mRNAs was increased in the liver of pre‐prandial pigs (P ≤ 0.05). Both AdipoR1 and AdipoR2 mRNA abundance tended to be increased in s. c. adipose tissue in the pre‐prandial pigs (P ≤ 0.1). The expression of the AdipoR genes in various tissues suggests the effect of adiponectin may be mediated through these receptors in porcine tissues. The nutritional status changes have an effect on the expression of porcine hepatic AdipoR genes and to a lesser extent adipose tissue genes, suggesting that the expression of these genes in the liver and the adipose tissue is responsive to the nutritional status.