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Reduced damage in the tissues of dates fed rats
Author(s) -
Habib Hosam M.,
Ibrahim Wissam H.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1018-b
Subject(s) - lactate dehydrogenase , creatinine , malondialdehyde , alkaline phosphatase , creatine kinase , lipid peroxidation , blood urea nitrogen , medicine , endocrinology , creatine , chemistry , alanine aminotransferase , zoology , biology , antioxidant , biochemistry , enzyme
The present study was undertaken to determine the effect of dates on tissue damage in rats. Male Wistar rats (8‐week‐old) were fed a basal diet (AIN‐93M) that contained 0%, 12%, or 24% dates for 30 days. All 3 diets were isonitrogenous and isocaloric. Rat body weights and feed intake were measured weekly. Neither body weight nor feed intake was significantly affected by any of the dietary treatments. At the end of the feeding period, rats were killed and serum was analyzed for the levels of the lipid peroxidation product malondialdehyde (MDA), aspartate aminotransferase (AST), alanine aminotranferase (ALT), lactate dehydrogenase (LDH), creatine kinase (CK), alkaline phosphatase (ALP), creatinine, and blood urea nitrogen (BUN). Compared to the control group, rats fed 12% dates had significantly lower levels of MDA, LDH, CK, and BUN while those fed 24% dates had significantly lower levels of MDA, AST, LDH, CK, creatinine, and BUN. Although the levels of all the biochemical indices analyzed were lower in rats fed 24% dates as compared to those fed 12% dates, the differences were not statistically significant at (P < 0.05). The results showed that at the levels fed dates can reduce tissue damage in vivo. The results also suggest that dates contain bioactive compounds that exhibit antioxidant properties.