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Conjugated linoleic acid (CLA) and vaccenic acid (VA) have no effect on blood pressure and isobar arterial elasticity in healthy young men
Author(s) -
Raff Marianne,
Tholstrup Tine,
Sejrsen Kristen,
Straarup Ellen Marie,
Wiinberg Niels
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1016
Subject(s) - blood pressure , medicine , sphygmomanometer , conjugated linoleic acid , pulse pressure , food science , zoology , endocrinology , chemistry , linoleic acid , biochemistry , biology , fatty acid
The objective was to examine the effect on blood pressure and isobar arterial elasticity (AEI) as a measure of arterial health of a commercial mixture of CLA and of milk fat produced to have a high content of VA. 60 healthy young men participated in this double‐blinded, randomized, 5 wk parallel intervention study. The participants substituted 115g of their daily fat intake with fat from one of three test diets: DCLA‐mix: rich in CLA (4.7g/d of c9,t11‐ and t10,c12‐CLA isomers in equal amounts), DVaccenic: rich in VA (4.1g/d), or DControl: a control diet with a low content of VA and CLA. Blood pressure and AEI (measured by an oscillometric method) was measured before and after the intervention period. There was a tendency to a higher systolic blood pressure after DCLA‐mix compared to DControl (P=0.07), but no difference in the effect of the test diets on diastolic blood pressure (P=0.37) or pulse pressure (P=0.80). There was no difference in isobar arterial compliance (P=0.52), distensibility (P=0.71), or volume (P=0.52). In conclusion, diets rich in milk fat and either CLA or VA have no adverse effect on blood pressure or AEI in healthy young men compared to a control diet. Sources of support: Danish Dairy Research Foundation and The Danish Research Development Program for Food Technology (Foetek).