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Rice Protein Isolates (RPI) Inhibit the onset of Atherogenesis in a Genetically Pre‐disposed Hypercholesterolemic Mouse Model
Author(s) -
Nagarajan Shanmugam,
Stewart Bradford W,
Ferguson Matthew E,
Badger Thomas M
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.5.a1000-a
Subject(s) - cholesterol , apolipoprotein e , casein , population , knockout mouse , chemistry , medicine , endocrinology , biology , food science , biochemistry , gene , disease , environmental health
Epidemiological studies strongly suggest that the reduced CVD incidence in the Asian population has been attributed to their dietary consumption of rice and soy. Rice protein isolates (RPI) have been shown to reduce cholesterol levels in clinical studies. Based on these reports, we hypothesize that RPI has anti‐atherosclerotic properties in preventing the onset of atherosclerosis. This hypothesis was addressed using the genetically predisposed apoE knockout (apo E−/ −) mouse model. Female apoE−/ − mice (4‐wk old, 20/group) were fed AIN‐93G diets formulated with casein (CAS) or RPI as their sole protein source for 10 weeks (14‐wk old). Plasma total cholesterol (n=20) and oxLDL (n=6) levels were not statistically different between the RPI‐fed and CAS‐fed groups. On the contrary, the anti‐oxLDL antibody response was significantly (n= 12, p<0.001) decreased in RPI‐fed compared to CAS‐fed animals. Interestingly, RPI suppressed the size of atherosclerotic lesions in the descending aorta (n= 7, p<0.001). In conclusion, the findings from this report suggest that consumption of rice‐based diets decreases the onset of atherosclerosis in this genetically predisposed hypercholesterolemic mouse model by mechanisms other than the lowering of serum lipids or oxLDL levels, possibly though such as cell adhesion and/or cell migration. Supported by the USDACRIS6251‐5100‐003‐06S