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Skin and muscle microvascular flows are altered with lower body pressure
Author(s) -
Zhang Qiuxia,
Keller Robert A,
Macias Brandon R,
Neuschwander Timothy B,
Hargens Alan R
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a805-b
Subject(s) - medicine , microcirculation , deconditioning , vasoconstriction , blood flow , vasodilation , cardiology , blood pressure , photoplethysmogram , filter (signal processing) , computer science , computer vision
Exposure to Lower Body Pressure (LBP) affects vascular transmural pressure which may affect local microcirculation due to vasoconstriction with negative LBP or vasodilatation with positive LBP. We hypothesize that microvascular blood flow (BF) decreases and microvascular blood volume (BV) increases during negative LBP, while BF increases and BV decreases during positive LBP. Five healthy subjects (3 males, 2 females) were positioned in a LBP chamber and a photoplethysmography probe was placed on the skin surface above the anterior tibial muscle to measure both skin and the muscle BF and BV. Measurement was made for 1 min baseline and 5 min of LBP at each of the following randomized pressures −40, −30, −20, −10, 10, 20, 30, 40 mmHg, followed by 5 min of recovery. Baseline value was normalized to 100%; all subsequent data (see table) were divided by this reference value (means ± SE). These results support that microvascular flow decreases and volume increases during negative LBP, while microvascular flow increases and volume decreases during positive LBP. Our results may be helpful in developing countermeasures to microgravity deconditioning as well as improving the health of patients on earth. Supported by NASA Grant, The Göteborg Medical Society and The Swedish Society of Medicine