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Changes of content of glutathione and metallothionein at plant cells and invertebrates treated by platinum group metals
Author(s) -
Kukacka Jiri,
Petrlova Jitka,
Prusa Richard,
Adam Vojtech,
Sures Bernd,
Beklova Miroslava,
Havel Ladislav,
Kizek Rene
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a75-d
Subject(s) - platinum , platinum group , cisplatin , metallothionein , chemistry , glutathione , invertebrate , environmental chemistry , biochemistry , pharmacology , catalysis , biology , ecology , medicine , enzyme , gene , chemotherapy
The biological activity of the first platinum based cytostatic drug – cisplatin was discovered in 1965. Since then hundreds of platinum(II) and platinum(IV) complexes have been synthesized and evaluated as anticancer agents over past 40 years. Besides that, platinum group metals has been intensively using as a part of catalytic exhaust gas converters. Because of the huge employment of platinum in pharmaceutical and automobile industry, it became necessary to study the influence of platinum group metals on living organisms. Here, we studied the influence of the metals (e.g. cisplatin) on concentration of small peptides and proteins (e. g. glutathione, metallothionein ‐ MT) on invertebrates and plant cell cultures, particularly, earthworms, tobacco BY‐2 cells and duckweed (0 – 160 μM of cisplatin). We found out that content of MT increased about 200 – 500 % with increasing cisplatin concentration at earthworms. MT amounts in the biological samples could be marker of environment pollution.