HEART RATE RECOVERY FOLLOWING PEAK EXERCISE IS ASSOCIATED WITH RESTING DIASTOLIC DYSFUNCTION IN HIV+ SUBJECTS

Objectives The objective was to examine the relationship between heart rate recovery (HRR) (peak HR‐HR at each minute post‐exercise) and diastolic function in HIV+ subjects (HIV+) and HIV‐negative controls (Cntl). Methods HIV+ (n=20, 40 ± 7 yrs) and Cntl subjects (n=10, 41 ± 10 yrs) underwent maximal exercise testing on a cycle ergometer with oxygen consumption and EKG monitoring. Resting 2D and Doppler echocardiography was performed on a separate day. Results Although no significant differences between groups, peak HR and peakVO 2 was significantly associated with 3, 4, and 5min HRR, and were used as covariates for comparison between groups. HRR at 3min(HIV+= 50.7 ± 3 vs. Cntl= 64.2 ± 4 bpm, p<0.007), 4min(HIV+= 56.5 ± 2 vs. Cntl=68.9 ± 4, p<0.01) and 5min (HIV+= 61.9 ± 3 vs. Cntl= 72.0 ± 4, p<0.06) was significantly lower in HIV+ than Cntl. HRR at 3min was associated with septal em (r=0.37, p<0.05), left ventricular mass index (LVMI)(r=‐0.42, p<0.03), and fasting glucose (r=‐0.37, p<0.04). HRR at 4min was associated with LVMI (r=‐0.32, p<0.009), fasting glucose (r=‐0.43, p<0.02) and serum triglycerides (TG)(r=‐0.39, p<0.04). HRR at 5min was associated with septal em (r=0.40, p<0.03), SBP (r=0.35, p<0.07), fasting glucose (r=0.40, p<0.03) and serum TG (r=0.50, p<0.007). HRR at 6‐ and 7min were also associated with septal em (r=0.46, p<0.001 and r=‐0.42, p<0.03, respectively). Conclusion Lower HRR following maximal exercise may predict diastolic dysfunction in HIV+ subjects and may be a useful screening tool in the detection of diastolic dysfunction in HIV+. Supported by the NIH.