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Lack of association between body mass index and acute hypertonic saline induced increases in blood pressure
Author(s) -
Kuczmarski James M,
Delaney Erin P,
Wenner Megan M,
Prettyman Allen V,
Stillabower Michael E,
Farquhar William B
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a737-b
Subject(s) - blood pressure , hypertonic saline , hematocrit , medicine , body mass index , tonicity , sodium , endocrinology , saline , diastole , mean arterial pressure , heart rate , anesthesia , chemistry , organic chemistry
Salt sensitivity of blood pressure (BP) is thought to be greater in obese subjects compared to normal weight individuals. The mechanisms underlying sodium‐induced increases in BP have not been fully elucidated. We hypothesized that body mass index (BMI) would be associated with sodium‐induced increases in BP. We retrospectively examined data from 44 healthy subjects (mean ± sem: 25±1 yrs) that completed a standardized 60‐minute intravenous infusion (0.15 ml/kg/min) of 3% sodium chloride (hypertonic saline infusion: HSI). The HSI protocol is a robust sodium and volume stimulus, and allows acute BP responses to be quantified. Blood pressure was assessed on a beat‐to‐beat basis non‐invasively with a Finometer. In this cohort, BMI ranged from 19‐35 kg/m2 (25±1 kg/m2). Serum sodium increased pre‐ to post‐infusion (135±0.6 vs. 141±0.4 mmol/L; p < 0.01) and hematocrit declined (39±0.7 vs. 36±0.6 %; p < 0.01) during the 60‐minute HSI. Baseline mean BP was 80±2 and this increased to 90±2 mmHg (p < 0.01) at the end of the infusion. BMI did not correlate with the increase in systolic BP (r=0.04, r2=0.002, p=0.78), diastolic BP (r=0.11, r2=0.013, p=0.47), or mean BP (r=0.03, r2=0.001, p=0.87). In conclusion, within a range of 19–35 kg/m2, there was no association between BMI and the hypertonic saline‐induced increase in BP. Supported by NIH grant R15 HL74851 and The University Of Delaware Undergraduate Research Office