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Adventitial contribution to restenosis after angioplasty
Author(s) -
ely dan,
Liu Bei,
Dunphy Gail
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a729-d
Subject(s) - restenosis , adventitia , angioplasty , medicine , elastin , lumen (anatomy) , constriction , cardiology , carotid arteries , artery , arterial wall , anatomy , pathology , stent
Remodeling of the vascular wall is a major contributor to restenosis after angioplasty. While the involvement of smooth muscle cells after angioplasty has been studied intensively, the role of an adventitial component has been largely ignored. The aim of this study was to examine the contribution of carotid artery adventitial changes to the development of restenosis after experimental angioplasty. Adult male spontaneous hypertensive rats were used. Experimental angioplasty was performed to the left common carotid artery, while the right served as the undamaged control. After 14 days, rats were euthanized, and carotid arteries (injured and control) were analyzed for the changes in each layer and their contributions to the remodeling of the vessel wall. Histological examination revealed that 1) the lumen of the injured vessel was significantly narrowed; 2) the media of injured carotids were thinner than controls; 3) vascular constriction was shown by the weaving appearance of the elastin in injured vessels only; 4) thickness of the adventitia and collagen accumulation in injured vessels were ~ 3 X that of controls; 5) thickness of the total wall in the injured vessels was over 4 X that of controls. In conclusion, adventitial changes in response to vessel injury may play a significant role in vascular wall remodeling and restenosis after angioplasty.