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Targeting Echogenic Immunoliposomes to Hypoxic Areas in the Infarcted Heart
Author(s) -
Scott Robert,
Wang Bin,
Pattillo Christopher B,
Brown Desmond,
Miller Larry,
Chong Parkson,
Kiani Mohammad F.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a713-a
Subject(s) - echogenicity , medicine , cardiology , hypoxia (environmental) , pathology , chemistry , radiology , ultrasound , oxygen , organic chemistry
Immunoliposome (IL) targeting to hypoxic areas after an acute myocardial infarction (MI) could provide the means by which pro‐angiogenic/vasculogenic compounds can be selectively targeted to the infarcted region and/or non‐invasively imaged. Immunoliposome accumulation and biodistribution was quantified in a rat model of MI following left coronary artery ligation. Radiolabeled anti‐P‐selectin ILs injected immediately post‐MI showed a 103% increase in targeting to infarcted myocardium when compared to adjacent normal myocardium. Radiolabeled anti‐P‐selectin ILs injected 4 hours post‐MI showed a 120% increase in targeting to infarcted myocardium when compared to adjacent normal myocardium. In our experiments, the targeting to upregulated P‐selectin provides the most promising potential target for selectively delivering compounds to infarct region of the myocardium as well as imaging these areas for use in in vivo biodistribution studies. We are currently developing echogenic immunoliposomes which can be used to image infarcted regions of the heart by ultrasound and to study the biodistribution of immunoliposomes in vivo . Funding provided by the American Heart Association