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The Ossabaw swine model of the Metabolic syndrome exhibit greater stenosis after coronary stenting than lean Yucatan swine.
Author(s) -
Edwards Jason Matthew,
Vuchetich Jim,
Mokelke Eric,
Alloosh Mouhamad,
March Keith,
Hou Dongming,
Sturek Michael
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a698-b
Subject(s) - medicine , cardiology , metabolic syndrome , stenosis , restenosis , intravascular ultrasound , diabetes mellitus , miniature swine , stent , coronary atherosclerosis , obesity , coronary artery disease , endocrinology
BACKGROUND Patients with the metabolic syndrome have poor prognosis after coronary stenting. Mechanisms underlying this pathology have been elusive because of the lack of a large animal model of the metabolic syndrome. HYPOTHESIS Lean Ossabaw swine predisposed to the metabolic syndrome (n=8; insulin‐resistant, propensity to obesity) will exhibit greater in‐stent stenosis after coronary stenting vs. lean Yucatan (n=4) swine. METHODS Bare metal stents were placed with 1x apposition (not over‐inflation injury) verified by intravascular ultrasound (IVUS). Stenosis was evaluated using IVUS and histology 3–4 weeks later. Stenosis was calculated from the cross sectional neointimal area as a percent of the area within the internal elastic lamina in the stented segment. RESULTS Mean percent stenosis in Ossabaw was greater than Yucatan by IVUS (26±7% vs. 7±3%) and histological analysis (67±8% vs. 34±7%). These data suggest that the risk for increased stenosis already exists in lean Ossabaw pigs with insulin resistance and predisposed to obesity. CONCLUSIONS Ossabaw miniature swine are a novel humanoid model of the metabolic syndrome uniquely suited for the study of coronary interventional devices and mechanisms of accelerated restenosis. Support: NIH RR13223, HL62552, American Diabetes Association.