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The FGF signaling pathway and human disease
Author(s) -
Ibrahimi Omar A,
Mohammadi Moosa
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a694-c
Subject(s) - fibroblast growth factor , regulator , signal transduction , biology , fibroblast growth factor receptor , microbiology and biotechnology , embryonic stem cell , receptor , genetics , gene
The FGF signaling pathway plays a ubiquitous role in human biology as a regulator of embryonic development, homeostasis and regenerative processes. Mutations in FGF receptors and FGFs lead to a diverse variety of diseases including skeletal, olfactory, and metabolic disorders as well as cancer. Recent biochemical and structural studies provide insight into the pathophysiological mechanisms by which these mutations act. Interestingly, these studies also provide significant understanding into the normal mechanisms of FGF–FGFR dimerization and binding specificity.