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Effects of sodium salicylate on spontaneous activity in the medial geniculate body
Author(s) -
Wang Jingye,
Yu Yanqin,
Xia Qiang
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a690-a
Subject(s) - sodium salicylate , tinnitus , medial geniculate body , chemistry , premovement neuronal activity , methyl salicylate , electrophysiology , sodium , neuron , pharmacology , medicine , neuroscience , anesthesia , biology , nucleus , audiology , inferior colliculus , ecology , organic chemistry
Ototoxicity of salicylate has been used to study tinnitus in animal models. Salicylate induced elevated central auditory activity has been interpreted as a correlate of tinnitus. Whether this elevated activity in the central auditory system is due to an increased activity in the medial geniculate body (MGB) is still not clear. To explore this issue, we recorded the spontaneous firing rates (SFRs) of the neurons in the MGB in anaesthetised rats following systemic injection of sodium salicylate . The SFRs of the neurons in the MGB of 8 rats were recorded by extracellular single unit recording with a tungsten electrode before and after injection of sodium salicylate (350mg/kg, i.p.). Out of 8 neurons recorded, 5 responded statistically significantly to the sodium salicylate by changing their SFRs and the others were not affected. Of the 5 neurons affected, 2 neurons showed increased while 3 neurons showed decreased firing rates. The SFRs of the 2 neurons increased gradually after salicylate application, with the maximum SFR in 20–30 min. While the SFRs of other 3 neurons decreased very rapidly in a few minutes after salicylate application, with the maximum decline of 400%. No spontaneous activity could be observed after 10 min in all of these 3 neurons, and there was no recovery of the SFRs after 3 hours of salicylate application. The altered response properties of MGB neurons indicate that the effect of salicylate is not always stimulatory to every component in the central auditory system. Further study is needed to verify the types of neurons in MGB.