Premium
ZINC HOMEOSTASIS AND REQUIREMENTS IN TODDLERS
Author(s) -
sheng xiaoyang,
Hambidge K. Michael,
Zhu Xixiang,
Ni Junxue,
Bailey Karl B.,
Gibson Rosalind S.,
Krebs Nancy F.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a628-b
Subject(s) - zinc , micronutrient , chemistry , bioavailability , toddler , population , zoology , medicine , biology , psychology , environmental health , organic chemistry , developmental psychology , pharmacology
Objective The first objective of this study was to estimate toddler requirements for zinc when consuming a diet with low phytate levels. The second objective was to evaluate and compare the zinc intake of rural and small town toddlers in southwest China in relation to these estimated zinc requirements. Design The home‐based study was designed to measure major variables of zinc homeostasis by giving one zinc stable isotope with all meals for one day as an extrinsic label and a second zinc stable isotope intravenously. Results No group or gender differences were found. Therefore results were combined for 43 toddlers aged 19–25 months whose major food staple was white rice. Salient results were: diet zinc [TDZ] 1.86±0.55 mg/day; fractional absorption of zinc [FAZ] 0.35±0.12; quantity of zinc absorbed [TAZ] 0.63±0.24 mg/day; endogenous fecal zinc [EFZ] 0.67±0.23 mg Zn/day; plasma zinc 65.0±8.3ug/dL. Dietary phytate:zinc molar ratio was 2.7:1. From these data the estimated physiologic zinc requirement for toddlers = 1.09mg Zn/day and estimated average dietary requirement 3.3 mg Zn/day. Conclusion These results suggest that current recommendations for toddlers are too low and that this population has suboptimal zinc intake. Support: Nestle Foundation, PN0312‐121, Shanghai Science and Technical Foundation 03JC14042.