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Familial aggregation of metabolic phenotypes in a Mongolian community population
Author(s) -
Seo JeongSun,
Cho SungIl,
Kim JongIl,
Kim HyungRae,
Lee Mi Kyeong,
Sung Joohon,
Kim Ho,
Choijamts Gotov
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a62-d
Subject(s) - heritability , genotyping , phenotype , biology , anthropometry , family aggregation , waist , genetics , population , offspring , medicine , demography , genotype , obesity , gene , environmental health , endocrinology , pregnancy , sociology
An important measure derived from familial aggregation is heritability. We estimated the heritability of metabolic phenotypes in a family study for gene mapping in Mongolia, where family size is relatively bigger than in most other Asian regions. Currently the study included 1318 individuals from 195 families, recruited from a rural community in Selenge province, Mongolia. The participants were composed of 13 ethnic groups, including 1050 KHALKH individuals. In terms of relationships, 345 grandparent‐grandchild, 800 parent‐offspring, 461 full‐sib pairs were found. Microsatellite genotyping procedure is ongoing. Phenotype measurements included detailed anthropometric indices, as well as various physiological markers. Pedigree verification was done by PREST software, and the heritability of each phenotype was calculated using SOLAR software. Overall heritability was respectively glucose 0.36, cholesterol 0.46, HDL 0.58, LDL 0.50, SBP 0.29, DBP 0.22, BMI 0.50 and waist circumference 0.36. The heritability showed comparable results to other successful gene mapping studies.