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Soy protein reduces insulin secretion through regulation of PPAR[gamma], PPAR[alpha], and GLUT 2 expression in pancreatic islets of obese rats
Author(s) -
NoriegaLópez Lilia G,
GonzálezGranillo Marcela,
Tovar Armando R,
Torres Nimbe
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a596-b
Subject(s) - medicine , endocrinology , pancreatic islets , insulin , soy protein , chemistry , islet , peroxisome proliferator activated receptor , glucose transporter , secretion , biology , receptor , biochemistry
Previous results in our lab have shown that consumption of 20% soy protein reduced 70% insulin secretion in isolated pancreatic islets. Thus, the purpose of the present work was to study the possible mechanism by which soy protein reduces insulin secretion. Studies in vivo using hyperglycemic clamp indicated that soy protein intake reduced 64% insulin secretion in comparison with rats fed casein. Studies in vitro with isolated pancreatic islets from rats fed soy protein showed lower expression of GLUT 2, SREBP‐1, PPARγ and PPARα compared with rats fed casein diet. Decrease in PPARα expression was associated with a low serum FFA concentration. One of the possible mechanisms that mediate insulin secretion in pancreatic islets of rats fed soy protein diet is through a reduction in the transcription factor PPARγ that regulates the lipogenic gene SREBP‐1, and the glucose transport GLUT 2. In addition, soy protein reduces FFA oxidation by decreasing PPPAα expression. This work was supported by CONACYT grant No 46135‐M.