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Soy protein reduces insulin resistance in skeletal muscle of obese Zucker fa/fa rats or in diet induced obesity (DIO)
Author(s) -
PalaciosGonzález Berenice,
Tovar Armando R,
Torres Nimbe
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a596-a
Subject(s) - medicine , endocrinology , lipotoxicity , insulin resistance , lipogenesis , skeletal muscle , triglyceride , insulin , chemistry , biology , adipose tissue , cholesterol
Insulin resistance occurs by the deleterious effect of the lipotoxicity developed during obesity. Increase in serum free fatty acids during obesity results in an increase in triglyceride content in skeletal muscle leading insulin resistance. Thus, the prevention of lipotoxicity in skeletal muscle will prevent or reduce insulin resistance. Therefore, the purpose of the present work was to establish if the type of dietary protein may prevent the accumulation of lipids in skeletal muscle by changing the expression of lipogenic and oxidative genes in two models of obesity. The results showed that rats fed soy protein diet by 160 days increased the oxidation capacity mediated by PPARδ, CPT‐1 and UCP‐3 than rats fed casein diet. These changes were more pronounced in obese Zucker fa/fa rats than rats with DIO. On the other hand, the consumption of casein diet in the two obesity models increased lipogenesis mediated by LXR, SREBP‐1c, and PGC1‐β, being more severe in Zucker fa/fa rats. However the consumption of soy protein diet reduced significantly the lipogenesis in skeletal muscle. This work was supported by CONACYT grant No 46135‐M.