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Dietary soy protein increases adipocyte functionality in a rat model of diet induced obesity (DIO)
Author(s) -
FrigoletVazquezVela Ma Eugenia,
Torres Nimbe,
Tovar Armando R
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a595-b
Subject(s) - medicine , endocrinology , soy protein , adipocyte , lipolysis , leptin , adipose tissue , lipogenesis , chemistry , casein , adiponectin , biology , obesity , food science , insulin resistance
Adipose tissue is now considered an endocrine organ in addition to the traditional role of energy storage. Adipocyte functionality has recently been defined as lipogenesis‐lipolysis homeostasis. Obesity‐related hypertrophy of adipocytes could be affecting normal adipocyte functionality with consequences as lipotoxic disorders. On the other hand, diet containing soy protein has been associated with decreased body mass and hipolypidemic effects. The aim of the present study was to assess the effect of soy protein on adipocyte functionality in vitro through lipogenic activity and leptin release from obese rats fed either casein or soy protein diets. Results indicate that adipocytes from abdominal or epidymal fat pad of rats fed soy protein had 1.3‐fold higher 14 C‐acetate incorporation into fatty acid compared with rats fed casein diet. Furthermore, abdominal adipocytes from rats fed high‐fat diets containing either casein or soy protein, released significantly more leptin than rats fed casein (1.8‐fold) or soy diets (0.61‐fold). These results suggest that soy protein induces metabolically active adipocytes and that dietary fat increases leptin secretion although it was higher in rats fed casein than those fed soy protein. This work was supported by CONACYT grant No 46135‐M.