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Similar effects of high fructose corn syrup and sucrose consumption on circulating levels of glucose, leptin, insulin and ghrelin.
Author(s) -
Melanson Kathleen J,
Zukley Linda,
Lowndes Joshua,
Nguyen Von,
Angelopoulos Theodore J,
Rippe James M
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a593-b
Subject(s) - leptin , ghrelin , high fructose corn syrup , fructose , insulin , endocrinology , sucrose , medicine , corn syrup , obesity , hormone , chemistry , food science , biology
Fructose has been implicated in potentially promoting obesity, due in part to a lack of insulin‐mediated leptin stimulation and ghrelin suppression. However, most work has examined the effects of pure fructose on these hormones and metabolism, rather than high‐fructose corn syrup (HFCS), which is the most commonly‐consumed form of fructose. Therefore the purpose of this study was to examine whether beverages sweetened with HFCS and those sweetened with sucrose (Suc), when consumed with mixed meals, would differ in their effects on blood glucose, insulin, leptin, and ghrelin Methods Thirty lean women were studied on two randomized 2‐day experimental visits to our metabolic unit during which HFCS and sucrose sweetened beverages were consumed with isocaloric diets on day 1 while blood was sampled. On day 2 of these visits, food was eaten ad libitum. Results No significant differences between the two experimental visits were seen in fasting values of plasma glucose, insulin, leptin, and ghrelin (p=NS). The within day variation in all four was not different between the two experimental visits. Net areas under the curve were similar for glucose insulin and leptin (p=NS). There were no differences in energy or macronutrient intake on day 2 (ad‐libtum feeding). Discussion These short‐term results suggest that when fructose is consumed in the form of HFCS, there are no differences in the metabolic effects in lean women compared to Suc. Further research is required to determine if the current findings hold true for obese individuals and males. Word Count: 1611