Premium
Weight Loss and Lipid Metabolism Improving Proprieties of a Chinese Herbal Formula WL2 in Diet‐Induced Obesity
Author(s) -
Yao Yisang,
Lu Jihong,
Zhang Lijuan,
Chen Wei,
Hua Yanjun,
Yin Weiti,
Zhu JiaShi
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a587
Subject(s) - weight loss , adiponectin , medicine , endocrinology , lipid metabolism , adipose tissue , obesity , cholesterol , lipid profile , metabolism , body weight , insulin resistance
We reported weight loss proprieties of SSP6 formula (FASEB J 19(4): A191, 2005). We now report the effects of another herbal formula, WL2, on weight loss and lipid metabolism. Male SD rats were pre‐fed a high‐calorie‐diet (HCD) for 10 wks to prior establish obesity. Obese rats were assigned randomly to WL2 (1.5 g/kg) and vehicle control groups, receiving WL2 or vehicle by gavage for 10 wks. Body weight (BW) was monitored throughout the study. Abdominal fat pads were recovered at Wk 10 of treatment, expressed as a weight ratio (FW) to BW. Fasting blood glucose (FBG), insulin (Ins), glucagon (Glg), adiponectin (Adn), and plasma triglycerides and cholesterol were tested. Reduced BW was seen with WL2 at Wk 3 and following weeks, as compared to controls (p<0.01). At Wk 10, BW and FW were significantly reduced with WL2 by 12% (p<0.001) and 40% (p<0.001), respectively. Plasma LDL cholesterol was decreased with WL2 by 39% (p=0.005), while HDL cholesterol was increased by 18% (p=0.001). Glg was decreased marginally by 6% (p=0.060). Adn was significantly decreased with WL2 by 27% (p=0.004). There were no significant changes in Ins, FBG, and TG. In conclusion, WL2 demonstrated good activities in weight loss and improving lipid metabolism in this DIO model. The suppressed Adn at Wk 10 may be due to the reduced mass of body adipose tissue. Further research will examine WL2’s benefits in humans with disturbed lipid metabolism and obesity.