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Influence of Sex, Age, and Metabolic Syndrome Status in Weight Loss Outcomes Using Very Low Calorie Diet in African American and Caucasian Obese Patients
Author(s) -
Hong Kurt,
Heber David
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a586-b
Subject(s) - weight loss , medicine , very low calorie diet , obesity , metabolic syndrome , calorie , endocrinology
Previous studies have demonstrated differences in weight loss in following dietary interventions in patients of different age and gender. It is unclear if such disparity exists for both African American (AA) and Caucasian (CAU) patients. We studied obese patients at a University weight loss center using VLCD (500–800 Cal/day). Primarily endpoint was weight loss at 12 weeks. Changes in body composition and other metabolic parameters were also assessed. A total of 1142 AA and CAU patients were enrolled. Baseline weight was not different between AA and CAU. After 12 weeks, comparable weight loss of 11.1 % and 11.6% was seen in CAU and AA men. Weight loss was also similar between AA (9.8%) and CAU (9.3%) women. Improvements in fasting glucose, lipids, blood pressures were observed in all four groups (P<0.01). Greater improvement in fasting glucose level was however seen in AA as compared to CAU (women −7.4% vs −3.9%; men −17.1% vs. −6.3%). When tiered by age (<40, 40–50, >50), no differences were observed for degree of weight loss among groups in either race. In women, race did not influence degree of improvement in MS profile; in men, attenuated improvements in diastolic BP (P<0.05) was seen in AA compared to CAU despite similar weight loss. In conclusion, obese men and women, regardless of race and age, were able to achieve significant weight loss utilizing VLCD, associated with marked improvement in obesity‐related comorbidities.