Premium
The long‐term effect of cereal fiber on weight, fasting glucose, insulin, cholesterol, triglycerides and free fatty acids in hyperinsulinemic humans
Author(s) -
Freeland Kristin Rae,
Wolever Thomas
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a584-c
Subject(s) - medicine , endocrinology , insulin , cholesterol , insulin resistance , weight gain , body weight
Canada Epidemiological studies have shown that a high intake of cereal fiber is associated with reduced plasma insulin and reduced weight gain. However, long‐term clinical studies establishing causation have not been conducted. We hypothesized that a long‐term increase in cereal fiber intake in hyperinsulinemic humans would result in reduced plasma glucose, insulin, FFA, and weight. Twenty seven hyperinsulinemic subjects were randomized to receive a control (C) (n=13) or fiber (F) (24g) (n=14) cereal daily for 1 year. Body weight was measured monthly and fasting blood samples collected at baseline, 3, 6, 9, and 12 months. There was no significant difference between the two treatments in change in weight or fasting cholesterol, triglycerides (TG) or FFA. There was a significant treatment X time interaction for change in fasting glucose (p=0.03) and insulin (p=0.05). Fasting glucose increased in the C group and decreased in the F group. Conversely, fasting insulin decreased in the C group and increased in the F group. In conclusion, a daily increase in cereal fiber intake may improve beta cell function.