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Risk for Metabolic Syndrome Does Not Impact Efficacy of Higher Protein Weight Loss Diet
Author(s) -
Walker D,
Evans E,
KrisEtherton P,
Layman D
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a584-a
Subject(s) - weight loss , metabolic syndrome , carbohydrate , medicine , obesity , endocrinology , zoology , chemistry , biology
Previous research has suggested diets with increased protein and reduced carbohydrates are more effective for individuals demonstrating insulin‐resistant characteristics of metabolic syndrome. The aim of this study was to determine if risk for metabolic syndrome modulates weight loss in response to diets varying in macronutrient content. Adults (N = 130; 45±9 y) were randomized to isocaloric diet treatments (F = 1700 and M = 1900 kcal/day) varying in macronutrient content (pro/carb/fat) for 4 mo: A) moderate protein (PRO; 1.6 g/kg‐day or 30/40/30%) OR B) higher carbohydrate (CARB; 0.8g/kg‐day or 15/55/30%). Treatment groups were blocked on gender and matched in BMI (32.5±4.4 kg/m 2 , p=0.45). Subjects were classified as high risk for metabolic syndrome by having triacylglycerol (TG) values > 1.6 mmol/L resulting in sample sizes of: PRO‐TG = 27; CARB‐TG = 24; PRO = 25; CARB = 26. Using 2‐way ANOVA (diet x TG status), a diet main effect was found favoring PRO in weight loss (−8.2±4.0 kg vs. −6.8±3.2 kg; p=0.048) and fat loss (−5.6±.8 kg vs. −4.5±1.9 kg; p=0.02), with no main effect of TG status [−7.0±3.7 kg (low) vs. −8.0±3.5 kg (high); p=0.23) or interactive effects (p=0.50). Higher protein weight loss diets are equally effective as higher carbohydrate diets on weight loss and correction of body composition in obese subjects with characteristics of metabolic syndrome. Support: IL Council on Food & Ag. Research, Kraft Foods, & National Cattleman’s Beef Assoc. (PI: Layman).