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The E23K polymorphism in Cuban Americans with and without type 2 diabetes
Author(s) -
Perez Gianna,
Huffman Fatma G.,
Tracey Martin,
Nath Subrata
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a578-a
Subject(s) - medicine , genotype , type 2 diabetes , blood pressure , endocrinology , insulin resistance , type 2 diabetes mellitus , diabetes mellitus , allele , genetics , biology , gene
KIR6.2 subunits form the pore of the K ATP channels in δ‐cells and in the heart. A variant of this gene, E23K, has been associated with type 2 diabetes (T2DM); while K ATP channels in the heart have been involved in the depression of cardiac function and the reduction of blood pressure (BP) variability. In T2DM hypertension commonly presents as a feature of the metabolic syndrome or insulin resistance, and both conditions have genetic predisposition as an important risk factor. The aim of this study was to investigate whether the E23K polymorphism was associated with T2DM and BP values in Cuban Americans (72 diabetics and 77 non‐diabetics). Anthropometrical indices and BP values were measured, and E23K was genotyped. There were no differences in genotype and allele frequencies between diabetics and non‐diabetics (χ 2 =0.22, p=0.895; χ 2 =0.11, p=0.735). Diastolic BP (DBP) varied with genotype, with E/E having the lowest values and K/K the highest. Analysis of covariance showed that the effect of genotype on DBP was marginally significant after controlling for age and T2DM. Further pairwise comparisons showed that DBP values for E/E were significantly lower than for K/K, but this did not hold true when the Holm¡ ¯ s modified Bonferroni technique was applied (p=0.028, α=0.025). Genotype was not significantly associated with systolic BP. Our study was limited in sample size and failed to detect any association between the E23K polymorphism and T2DM; however, it suggests a possible association with DBP values independently of T2DM and warrants studies to explore this relationship in detail.