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Aspirin‐induced restoration of the impaired plasma maspin level in human breast cancer
Author(s) -
Kahn Nighat,
Sinha Asru Kumar
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a523-d
Subject(s) - maspin , breast cancer , medicine , aspirin , cancer , ingestion , nitric oxide , plasma levels , gastroenterology , oncology , endocrinology , metastasis
Maspin, an anit breast cancer protein, is produced in the normal mammary cells but not in the malignant breast cancer cells. We investigated the effect of aspirin‐induced increase of plasma nitric oxide (NO) on plasma maspin production in breast cancer patients. Fifteen cancer patients (35–65 yrs), who had not undergone any cancer therapy and 15 age matched normal volunteers participated in the study. The subjects had abstained from all medication for 2 weeks. All subjects ingested aspirin (150 mg). Plasma NO and maspin levels were determined before and after 60 min after the ingestion of aspirin. The plasma maspin increased from 0.95±0.012 to 4.63±0.02 nM (p<0.001). The plasma NO increased from 0.60±0.03 to 2.08±0.3 μM in breast cancer patients. In normal volunteers the plasma maspin increased from 4.76±0.041 to 9.36±0.036 nM (p<0.001) and NO increased from 2.15±0.08 to 3.36±0.04 μM. These results indicated that ingestion of aspirin might be beneficial for breast cancer patients through increased maspin production.