Premium
Expression of cFos and ICER within the Supraoptic Nucleus
Author(s) -
Jones Heath Gaedke,
Cunningham Tom,
Gottlieb Helmut B.,
Ji Lisa,
Flemming Tiffany,
Penny Maurice
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a463-c
Subject(s) - lamina terminalis , median preoptic nucleus , supraoptic nucleus , osmoregulation , vasopressin , subfornical organ , medicine , endocrinology , biology , homeostasis , hypothalamus , ecology , angiotensin ii , salinity , blood pressure
Osmoregulation of body fluids is vital for maintaining homeostasis in intracellular and extracellular fluid volumes throughout the body. The brain participates in osmoregulation by controlling drinking behavior, hormone release and the autonomic nervous system. The lamina terminalis region of the brain contains regions such as the subforincal organ, the organum vasculosum of the lamina terminalis (OVLT) and the median preoptic nucleus (MnPO), which are all involved in osmoregulation. These areas help control the release of the vasopressin, the anti‐diuretic hormone, through their projections to the supraoptic nucleus (SON). Water deprivation in rats increases the expression of the inducible transcription factor c‐Fos in the MnPO, OVLT, and SON. In this study, we tested the hypothesis that water deprivation would change the expression of another inducible transcription factor known as Inducible cyclic AMP Early Repressor (ICER) in these areas. Immunocytochemistry was used to look for changes in c‐Fos and ICER staining associated with water deprivation and rehydration with water. The results indicate that water deprivation significantly increases both ICER and c‐Fos staining in the SON. These findings suggest that water deprivation activates multiple transcription factor pathways in the SON. Funding was provided by the NIH Grants # RO1 HL55692 and # RO1 DK57822.