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Apoptotic Cells Initiate Endothelial Cell Sprouting via Electrostatic Signaling
Author(s) -
weihua zhang,
Tsan Rachel,
Schroit Alan,
Fidler Isaiah J.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a440-a
Subject(s) - microbiology and biotechnology , angiogenesis , sprouting , endothelial stem cell , sprouting angiogenesis , apoptosis , mechanism (biology) , cell , chemistry , biology , neovascularization , in vitro , cancer research , biochemistry , botany , philosophy , epistemology
Angiogenesis, the development of new blood vessels from preexisting vessels, is crucial to tissue growth, repair, and maintenance. This process begins with the formation of endothelial cell sprouts followed by the proliferation and migration of neighboring endothelial cells along the pre‐formed extensions. The initiating event and mechanism of sprouting is not known. We demonstrate that the phenotypic expression of a negatively‐charged surface membrane in apoptotic cells initiates the formation of directional endothelial cell sprouts that extend toward the dying cells by a charge‐dependent mechanism that is independent of diffusible molecules.