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Chronic adaptation to high protein intake during energy restriction leads to increased post‐prandial energy expenditure and fat oxidation in women
Author(s) -
Campbell Wayne W,
Carnell Nadine S,
Mattes Richard D,
Leidy Heather J
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a427-a
Subject(s) - meal , medicine , endocrinology , chemistry
Objective To examine the effects of acute high‐protein (HP) vs normal‐protein (NP) meals on post‐prandial energy expenditure (PPEE) in women who were chronically consuming a high‐protein (C‐HP) vs normal‐protein (C‐NP) energy‐restriction (ER), weight‐loss diet. Methods On 2 occasions, 38 women who were following a 12‐week, 750 kcal/day deficit (wt. loss: −6.9 ± 0.3 kg) diet of HP (30% protein; 45% CHO; 25% fat; 40% of protein from pork) or NP (18% protein; 57% CHO; 25% fat; no‐striated tissue) consumed a HP or NP breakfast meal of 25% of their ER diet. PPEE was measured over 4 h. Results PPEE was higher than fasting EE for all groups (P<0.001). Differential PPEE responses to the HP and NP meals were observed between the C‐HP and C‐NP groups. Specifically, the HP meal led to a greater PPEE for C‐HP (0.156 ± 0.016 kcal/min) vs C‐NP (0.108 ± 0.014 kcal/min) (P<0.05). In contrast, PPEE was not different between the C‐HP (0.130 ± 0.015 kcal/min) vs C‐NP (0.143 ± 0.014 kcal/min) when the NP meal was consumed. Respiratory exchange ratio was lower in the C‐HP vs C‐NP groups following HP (0.818 ± 0.005 vs 0.838 ± 0.007) (P<0.05) and NP (0.824 ± 0.009 vs 0.852 ± 0.007) (P<0.05) meals. Comparable results were shown for increased fat oxidation (HP meal: 0.062 ± 0.003 g/min vs 0.049 ± 0.002 g/min (P<001); NP meal: 0.058 ± 0.004g/min vs 0.045 ± 0.003 g/min (P<0.01)). Conclusions These results suggest that a chronic adaptation to HP diets exists leading to metabolic priming and increased energy expenditure and fat oxidation with acute HP meal consumption. Supported by The National Pork Board.