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Pre‐ and postoperative comparison of metabolic efficiency after surgical resection of large lower‐extremity
Author(s) -
Price Chrystal,
Camporesi Enrico M.
Publication year - 2006
Publication title -
the faseb journal
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.709
H-Index - 277
eISSN - 1530-6860
pISSN - 0892-6638
DOI - 10.1096/fasebj.20.4.a396-a
Subject(s) - workload , medicine , treadmill , heart rate , anesthesiology , surgery , physical therapy , anesthesia , blood pressure , computer science , operating system
Oxygen consumption (VO 2 ) required for a set workload is a predictor of metabolic efficiency; the presence of a large tumor mass can alter oxygen consumption. The goal of this preliminary project was to analyze the effects of the resection of lower‐extremity soft‐tissue tumors on metabolic efficiency during submaximal steady‐state exercise. Preoperative (baseline) and postoperative (2 year follow‐up) analysis was performed by measuring VO 2 and heart rate at a designated workload during a submaximal steady state exercise protocol. The workload was patient‐selected to a level that could be performed for at least 5 minutes on a walking treadmill, and the test was terminated on fatigue or following 10 minutes of exercise. Average heart rates for the preoperative time points were not different than postoperative 2 year follow‐up measurements (p>0.05). Changes in oxygen consumption (VO 2 ) could then be compared at a set workload. Postoperative VO 2 measurements at the 2 year follow‐up were significantly lower than preoperative VO 2 , indicating higher preoperative submaximal oxygen consumption and improved postoperative metabolic efficiency. These preliminary data suggest that the resection of lower‐extremity soft‐tissue tumors can result in an improved metabolic efficiency at two years postoperative follow‐up. Funded by the Department of Anesthesiology, SUNY Upstate Medical University.